(v) modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished
v. t. [ imp. & p. p. Denaturalized p. pr. & vb. n. Denaturalizing. ] [ Cf. F. dénaturaliser. ] 1. To render unnatural; to alienate from nature. [ 1913 Webster ]
2. To renounce the natural rights and duties of; to deprive of citizenship; to denationalize. [ R. ] [ 1913 Webster ]
They also claimed the privilege, when aggrieved, of denaturalizing themselves, or, in other words, of publicly renouncing their allegiance to their sovereign, and of enlisting under the banners of his enemy. Prescott. [ 1913 Webster ]
v. t. [ De- + nature. ] To deprive of its natural qualities; change the nature of. [ Webster 1913 Suppl. ]
2. to render (ethyl alcohol) unfit to drink by adding in toxic or unpalatable substances (such as benzene or pyridine) which nevertherless permit alcohol to be used as a solvent. [ PJC ]
3. modify the tertiary structure of (a protein or nucleic acid) so as to reduce or destroy its characteristic biological activity. Bioactive macromolecules such as enzymes or DNA may be denatured by heat, acid, alkali, or solvent treatment; the extent of such treatment required to denature a molecule varies with the specific compound. In some cases the denatured molecules may regain their original properties (renature) by other treatments. Denaturation may also cause a change in the physical properties of such molecules, e.g. proteins may become insoluble in water. [ PJC ]
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